Polypoid Mucosa With Eosinophilia and Glandular Hyperplasia in Chronic Sinusitis: A Histopathological and Immunohistochemical Study
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Polypoid Mucosa With Eosinophilia and Glandular Hyperplasia in Chronic Sinusitis: A Histopathological and Immunohistochemical Study
Auteurs : Gilead Berger [Israël] ; Avi Kattan [Israël] ; Joelle Bernheim [Israël] ; Dov Ophir [Israël]Source :
- The Laryngoscope [ 0023-852X ] ; 2002-04.
English descriptors
- Teeft :
- Acta otolaryngol, Allergic, Allergy, Allergy clin immunol, Antibiotic, April, Asthma, Bronchial asthma, Chronic inflammation, Chronic maxillary sinusitis, Chronic rhinosinusitis, Chronic sinusitis, Connective tissue, Control patients, Control subjects, Eosinophil, Eosinophilia, Epithelium, Ethmoid, Ethmoid mucosa, Frontal sinus, Glandular, Glandular hyperplasia, Histopathological, Histopathological types, Hyperplasia, Immunohistochemical, Inflammation, Inflammatory, Inflammatory cells, Kfar saba, Lamina propria, Laryngoscope, Lymphocyte, Maxillary, Maxillary sinus, Median, Median value, Mucosa, Mucosal, Mucus, Mucus production, Nasal, Nasal polyposis, Neck surgery, Normal control subjects, Normal sinus mucosa, Obstruction, Original magnification, Other hand, Otolaryngol, Pathological conditions, Plasma cells, Polypoid, Polypoid mucosa, Significant difference, Significant increase, Sinus, Sinus involvement, Sinus mucosa, Sinusitis, Submucosal, Submucosal seromucous glands, Superficial zone, Tissue eosinophilia.
Abstract
Objective To evaluate the histopathological and immunohistochemical characteristics of chronic sinusitis, with reference to the extent of sinus involvement.
Study Design A nonrandomized, retrospective, controlled qualitative and quantitative study.
Methods Twenty‐nine adults with refractory chronic sinusitis underwent functional endoscopic sinus surgery. The score of computed tomography scans was used to determine the extent of disease. Six patients with normal sinus mucosae served as control subjects. Specimens underwent routine histological processing and hematoxylin‐eosin and periodic acid–Schiff staining. Immunohistochemistry for T and B lymphocytes was applied. Low‐magnification microscopy was designed to yield typical pathological features, and high magnification to count various inflammatory cells.
Results Patients were divided into two groups according to their dominant pathological features: 16 had polypoid mucosa and eosinophilia, and 13 had glandular hyperplasia. The number of eosinophils, T and B lymphocytes in the lamina propria was significantly higher in patients with polypoid mucosa and eosinophilia, compared with those with glandular hyperplasia and with normal control subjects, whereas the difference between patients with glandular hyperplasia and control subjects was insignificant. Although the overall inflammatory reaction was relatively modest, nasal polyposis was more prevalent in patients with polypoid mucosa and eosinophilia; likewise, computed tomography revealed a significantly more extensive disease in these patients compared with the patients with glandular hyperplasia.
Conclusion Two pathophysiological pathways, inducing prolonged obstruction to the outflow of sinus secretion and ultimately causing chronic inflammation, are suggested: 1) swollen polypoid mucosa with activation of eosinophils that damage the epithelium and 2) continued increased mucus secretion originated from hyperplastic submucosal seromucous glands.
Url:
DOI: 10.1097/00005537-200204000-00026
Affiliations:
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sortKey="Kattan, Avi" sort="Kattan, Avi" uniqKey="Kattan A" first="Avi" last="Kattan">Avi Kattan</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Otolaryngology—Head and Neck Surgery, Meir General Hospital, Kfar Saba</wicri:regionArea><wicri:noRegion>Kfar Saba</wicri:noRegion></affiliation></author><author><name sortKey="Bernheim, Joelle" sort="Bernheim, Joelle" uniqKey="Bernheim J" first="Joelle" last="Bernheim">Joelle Bernheim</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pathology, Meir General Hospital, Kfar Saba</wicri:regionArea><wicri:noRegion>Kfar Saba</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Ophir, Dov" sort="Ophir, Dov" 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Inc.</publisher><pubPlace>Hoboken, NJ</pubPlace><date type="published" when="2002-04">2002-04</date></imprint><idno type="ISSN">0023-852X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-852X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta otolaryngol</term><term>Allergic</term><term>Allergy</term><term>Allergy clin immunol</term><term>Antibiotic</term><term>April</term><term>Asthma</term><term>Bronchial asthma</term><term>Chronic inflammation</term><term>Chronic maxillary sinusitis</term><term>Chronic rhinosinusitis</term><term>Chronic sinusitis</term><term>Connective tissue</term><term>Control patients</term><term>Control subjects</term><term>Eosinophil</term><term>Eosinophilia</term><term>Epithelium</term><term>Ethmoid</term><term>Ethmoid mucosa</term><term>Frontal sinus</term><term>Glandular</term><term>Glandular hyperplasia</term><term>Histopathological</term><term>Histopathological types</term><term>Hyperplasia</term><term>Immunohistochemical</term><term>Inflammation</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Kfar saba</term><term>Lamina propria</term><term>Laryngoscope</term><term>Lymphocyte</term><term>Maxillary</term><term>Maxillary sinus</term><term>Median</term><term>Median value</term><term>Mucosa</term><term>Mucosal</term><term>Mucus</term><term>Mucus production</term><term>Nasal</term><term>Nasal polyposis</term><term>Neck surgery</term><term>Normal control subjects</term><term>Normal sinus mucosa</term><term>Obstruction</term><term>Original magnification</term><term>Other hand</term><term>Otolaryngol</term><term>Pathological conditions</term><term>Plasma cells</term><term>Polypoid</term><term>Polypoid mucosa</term><term>Significant difference</term><term>Significant increase</term><term>Sinus</term><term>Sinus involvement</term><term>Sinus mucosa</term><term>Sinusitis</term><term>Submucosal</term><term>Submucosal seromucous glands</term><term>Superficial zone</term><term>Tissue eosinophilia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective To evaluate the histopathological and immunohistochemical characteristics of chronic sinusitis, with reference to the extent of sinus involvement.</div><div type="abstract">Study Design A nonrandomized, retrospective, controlled qualitative and quantitative study.</div><div type="abstract">Methods Twenty‐nine adults with refractory chronic sinusitis underwent functional endoscopic sinus surgery. The score of computed tomography scans was used to determine the extent of disease. Six patients with normal sinus mucosae served as control subjects. Specimens underwent routine histological processing and hematoxylin‐eosin and periodic acid–Schiff staining. Immunohistochemistry for T and B lymphocytes was applied. Low‐magnification microscopy was designed to yield typical pathological features, and high magnification to count various inflammatory cells.</div><div type="abstract">Results Patients were divided into two groups according to their dominant pathological features: 16 had polypoid mucosa and eosinophilia, and 13 had glandular hyperplasia. The number of eosinophils, T and B lymphocytes in the lamina propria was significantly higher in patients with polypoid mucosa and eosinophilia, compared with those with glandular hyperplasia and with normal control subjects, whereas the difference between patients with glandular hyperplasia and control subjects was insignificant. Although the overall inflammatory reaction was relatively modest, nasal polyposis was more prevalent in patients with polypoid mucosa and eosinophilia; likewise, computed tomography revealed a significantly more extensive disease in these patients compared with the patients with glandular hyperplasia.</div><div type="abstract">Conclusion Two pathophysiological pathways, inducing prolonged obstruction to the outflow of sinus secretion and ultimately causing chronic inflammation, are suggested: 1) swollen polypoid mucosa with activation of eosinophils that damage the epithelium and 2) continued increased mucus secretion originated from hyperplastic submucosal seromucous glands.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Berger, Gilead" sort="Berger, Gilead" uniqKey="Berger G" first="Gilead" last="Berger">Gilead Berger</name></noRegion><name sortKey="Berger, Gilead" sort="Berger, Gilead" uniqKey="Berger G" first="Gilead" last="Berger">Gilead Berger</name><name sortKey="Berger, Gilead" sort="Berger, Gilead" uniqKey="Berger G" first="Gilead" last="Berger">Gilead Berger</name><name sortKey="Berger, Gilead" sort="Berger, Gilead" uniqKey="Berger G" first="Gilead" last="Berger">Gilead Berger</name><name sortKey="Bernheim, Joelle" sort="Bernheim, Joelle" uniqKey="Bernheim J" first="Joelle" last="Bernheim">Joelle Bernheim</name><name sortKey="Bernheim, Joelle" sort="Bernheim, Joelle" uniqKey="Bernheim J" first="Joelle" last="Bernheim">Joelle Bernheim</name><name sortKey="Kattan, Avi" sort="Kattan, Avi" uniqKey="Kattan A" first="Avi" last="Kattan">Avi Kattan</name><name sortKey="Ophir, Dov" sort="Ophir, Dov" uniqKey="Ophir D" first="Dov" last="Ophir">Dov Ophir</name><name sortKey="Ophir, Dov" sort="Ophir, Dov" uniqKey="Ophir D" first="Dov" last="Ophir">Dov Ophir</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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